Classic polyarteritis nodosa presenting rare clinical manifestations in a patient with hemophilia A.

摘要: A 35-year-old patient with hemophilia presented rapidly progressive polyarteritis nodosa (PAN). He had been infected hepatitis B virus (HBV) by repeated transfusion and was positive for surface antigen but negative antibody.The symptoms of acute epididymitis followed emergency admission because appendicitis. On day 7 admission, he complained severe back pain, computerized tomography (CT) showed massive perirenal hematoma. 49, mild monoplegia in the left arm suddenly developed, CT magnetic resonance imaging revealed multiple cerebral infarctions. Factor VIII replacement therapy attenuated; however, infarction extended throughout hemispheres. diagnosed classic (cPAN), pulse methylprednisolone continued.The died supratentorial herniation, autopsy that vasculitis associated intimal thickening present liver, pancreas, intestine, kidneys, larger-sized arteries. The development cPAN appeared to have originated from chronic HBV infection, this is first report patients. Concomitant hemorrhagic thrombotic manifestations are hardly treatable patients coagulation disorders, current case may represent a rare transfusion-related complication