New insights in the pathogenesis and treatment of normal tension glaucoma

摘要: Increased intraocular pressure (IOP) is a major risk factor for glaucomatous damage and reducing IOP improves prognosis. Nevertheless, there little doubt that other factors besides such as unstable ocular perfusion are involved. Blood flow if either the fluctuates at high level (or blood low level) or autoregulation of disturbed. A common cause disturbed OBF primary vascular dysregulation (PVD) frequently observed in normal tension glaucoma patients. An leads to recurrent mild reperfusion injury (chronic oxidative stress) affecting particularly mitochondria optic nerve head. regulation can be improved by magnesium, calcium channel blockers well with carbonic anhydrase inhibitors.