Development and validation of a simplified predictive index for major complications in contemporary percutaneous transluminal coronary angioplasty practice

作者: Stephen E. Kimmel , Jesse A. Berlin , Brian L. Strom , Warren K. Laskey

DOI: 10.1016/0735-1097(95)00294-4

关键词: Stepwise regressionInternal medicineCardiologyLogistic regressionAngioplastyMedicineRisk assessmentMyocardial infarctionBypass surgeryRisk factorUnstable angina

摘要: Objectives. This study was designed to determine the preprocedural risk factors for major complications (emergent coronary bypass surgery, myocardial infarction or death) of angioplasty and derive validate a simplified index that predicts patients' priori complications. Background. Previous studies after may not be generalizable current, broad-based practice. Furthermore, our knowledge clinically useful predictive has been derived independently validated. Methods. From data collected prospectively Registry Society Cardiac Angiography Interventions 1992, multivariable logistic regression used which variables were associated with in 10,622 first procedures. Stepwise receiver operating characteristic curves then this registry develop validated using 5,250 procedures 1993 registry. Results. Predictors multivessel disease, unstable angina, recent infarction, type C lesion left main angioplasty, shock, age, geographic region absence previous surgery. The consisted six these plus aortic valve disease classified patients into four groups: low (1.3% complications), moderate (2.8%), high (12.7%) very (29.7%) risk. demonstrated consistent reliability discriminatory ability when applied data. Conclusions. identified selected populations also apply currently variables, can stratify groups before thus aiding assessment, resource allocation adjustment.

参考文章(35)
Julie E. Buring, Sherry L. Mayrent, Charles H. Hennekens, Epidemiology in Medicine ,(1987)
Stanley Lemeshow, David W. Hosmer, Applied Logistic Regression ,(1989)
David R Holmes, Richard Holubkov, Ronald E Vlietstra, Sheryl F Kelsey, Guy S Reeder, Gerald Dorros, David O Williams, Michael J Cowley, David P Faxon, Kenneth M Kent, Lamberto G Bentivoglio, Katherine Detre, The Co-Investigators of the National, Lung Heart, Percutaneous Transluminal Coronary Angioplasty Registry, None, Comparison of complications during percutaneous transluminal coronary angioplasty from 1977 to 1981 and from 1985 to 1986: The National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry Journal of the American College of Cardiology. ,vol. 12, pp. 1149- 1155 ,(1988) , 10.1016/0735-1097(88)92593-4
Carolyn K. Wells, Alvan R. Feinstein, Stephen D. Walter, A comparison of multivariable mathematical methods for predicting survival-III. Accuracy of predictions in generating and challenge sets Journal of Clinical Epidemiology. ,vol. 43, pp. 361- 372 ,(1990) , 10.1016/0895-4356(90)90122-6
Bruce A. Bergelson, Alice K. Jacobs, L.Adrienne Cupples, Nicholas A. Ruocco, Michael G. Kyller, Thomas J. Ryan, David P. Faxon, Prediction of risk for hemodynamic compromise during percutaneous transluminal coronary angioplasty. American Journal of Cardiology. ,vol. 70, pp. 1540- 1545 ,(1992) , 10.1016/0002-9149(92)90454-7
John H. Wasson, Harold C. Sox, Raymond K. Neff, Lee Goldman, Clinical prediction rules. Applications and methodological standards. The New England Journal of Medicine. ,vol. 313, pp. 793- 799 ,(1985) , 10.1056/NEJM198509263131306