Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.

作者: Seok-Rae Park

DOI: 10.4110/IN.2012.12.6.230

关键词: Cell biologySomatic hypermutationAntibodyActivation-induced (cytidine) deaminaseB cellAntigenGerminal centerImmune systemMedicineCytidine deaminaseImmunology

摘要: … Activation-induced cytidine deaminase (AID) is an enzyme that is predominantly expressed … Furthermore, AID stabilization and targeting are determined by post-translational …

参考文章(117)
Seok-Rae Park, Hong Zan, Zsuzsanna Pal, Jinsong Zhang, Ahmed Al-Qahtani, Egest J Pone, Zhenming Xu, Thach Mai, Paolo Casali, HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nature Immunology. ,vol. 10, pp. 540- 550 ,(2009) , 10.1038/NI.1725
Alexandre Orthwein, Astrid Zahn, Stephen P Methot, David Godin, Silvestro G Conticello, Kazutoyo Terada, Javier M Di Noia, Optimal functional levels of activation‐induced deaminase specifically require the Hsp40 DnaJa1 The EMBO Journal. ,vol. 31, pp. 679- 691 ,(2012) , 10.1038/EMBOJ.2011.417
J. Stavnezer, Molecular processes that regulate class switching. Current Topics in Microbiology and Immunology. ,vol. 245, pp. 127- 168 ,(2000) , 10.1007/978-3-642-59641-4_6
Zhenming Xu, Zsolt Fulop, Guikai Wu, Egest J Pone, Jinsong Zhang, Thach Mai, Lisa M Thomas, Ahmed Al-Qahtani, Clayton A White, Seok-Rae Park, Petra Steinacker, Zenggang Li, John Yates III, Bruce Herron, Markus Otto, Hong Zan, Haian Fu, Paolo Casali, None, 14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′–rich switch regions for class switch recombination Nature Structural & Molecular Biology. ,vol. 17, pp. 1124- 1135 ,(2010) , 10.1038/NSMB.1884
Rushad Pavri, Michel C. Nussenzweig, AID targeting in antibody diversity. Advances in Immunology. ,vol. 110, pp. 1- 26 ,(2011) , 10.1016/B978-0-12-387663-8.00005-3
Thomas Seidl, Trevor Whittall, Kaboutar Babaahmady, Thomas Lehner, B‐cell agonists up‐regulate AID and APOBEC3G deaminases, which induce IgA and IgG class antibodies and anti‐viral function Immunology. ,vol. 135, pp. 207- 215 ,(2012) , 10.1111/J.1365-2567.2011.03524.X
Siim Pauklin, Svend K. Petersen-Mahrt, Progesterone inhibits activation-induced deaminase by binding to the promoter. Journal of Immunology. ,vol. 183, pp. 1238- 1244 ,(2009) , 10.4049/JIMMUNOL.0803915
Camil Elie Sayegh, Melanie W Quong, Yasutoshi Agata, Cornelis Murre, E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nature Immunology. ,vol. 4, pp. 586- 593 ,(2003) , 10.1038/NI923
M. Jankovic, D. F. Robbiani, Y. Dorsett, T. Eisenreich, Y. Xu, A. Tarakhovsky, A. Nussenzweig, M. C. Nussenzweig, Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 187- 192 ,(2010) , 10.1073/PNAS.0908946107
Junji Komori, Hiroyuki Marusawa, Takafumi Machimoto, Yoko Endo, Kazuo Kinoshita, Tadayuki Kou, Hironori Haga, Iwao Ikai, Shinji Uemoto, Tsutomu Chiba, Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma Hepatology. ,vol. 47, pp. 888- 896 ,(2008) , 10.1002/HEP.22125