作者: Pärt Peterson , Tõnis Org , Ana Rebane
DOI: 10.1038/NRI2450
关键词: Autoimmunity 、 Transcriptional regulation 、 Self Tolerance 、 Biology 、 Regulation of gene expression 、 Central tolerance 、 Transcription factor 、 Cell biology 、 Autoimmune regulator 、 Immunology 、 Negative selection
摘要: The negative selection of T cells in the thymus is necessary for the maintenance of self tolerance. Medullary thymic epithelial cells have a key function in this process as they express a …