Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

作者: Pärt Peterson , Tõnis Org , Ana Rebane

DOI: 10.1038/NRI2450

关键词: AutoimmunityTranscriptional regulationSelf ToleranceBiologyRegulation of gene expressionCentral toleranceTranscription factorCell biologyAutoimmune regulatorImmunologyNegative selection

摘要: The negative selection of T cells in the thymus is necessary for the maintenance of self tolerance. Medullary thymic epithelial cells have a key function in this process as they express a …

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