Measurements of Glycogen Metabolism in the Living Brain
作者： Rolf Gruetter
DOI: 10.1007/978-1-4614-1788-0_22
关键词: Neuroprotection 、 Glycogen metabolism 、 Internal medicine 、 13c nmr spectroscopy 、 Hypoglycemia 、 Context (language use) 、 Glycogen 、 Endocrinology 、 Metabolism 、 Ischemia 、 Biology
摘要: To maintain brain function, the combustion of glucose for generation energy (ATP) is essential, yet maintains fuel storage in form glial glycogen. Although glycogen levels are lower than those liver, they exceed normal free concentration several-fold. Under normoxic conditions, when a partial supply deficit present, can provide extended periods time. Brain metabolism active, but comparatively slow, consistent with role an emergency neuroprotective effects. The classical analysis biochemical means requires tissue extraction; be measured directly living only by 13C NMR spectroscopy. This chapter reviews insights gained into to-date and potential roles context neuro-glial metabolism, hypoglycemia neuroprotection.
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