Fetal circulatory responses to oxygen lack.

摘要: The knowledge on fetal and neonatal circulatory physiology accumulated by basic scientists clinicians over the years has contributed considerably to recent decline of perinatal morbidity mortality. This review will summarize peculiarities circulation, distribution organ blood flow during normoxemia, that oxygen lack caused various experimental perturbations. Furthermore, relation between delivery tissue metabolism as well evidence support a new concept be presented along with principal cardiovascular mechanisms involved. Finally, organs examined discussed in function. response hypoxemia asphyxia is centralization favour brain, heart, adrenals at expense almost all peripheral organs, particularly lungs, carcass, skin scalp. qualitatively similar but quantitatively different under conditions. However, nadir severe acute cannot maintained. Then there decentralization, fetus experience brain damage if not expire unless immediate resuscitation occurs. Future work this field have concentrate important questions, what factors determine collapse compensating fetus, how does it relate neuronal damage, can pharmacologically protected against adverse effects asphyxia.