Change of Fecal Flora and Effectiveness of the Short-term VSL#3 Probiotic Treatment in Patients With Functional Constipation.

摘要: Background/aims We investigated gut flora characteristics in patients with functional constipation (FC) and influences of short-term treatment VSL#3 probiotic on symptom improvement. Methods Thirty fulfilling Rome III criteria for FC 30 controls were enrolled. Fecal samples obtained before after intake (one sachet twice daily 2 weeks) examined by quantitative real-time polymerase chain reaction (qRT-PCR). Symptom changes also investigated. Results The fold differences Bifidobacterium Bacteroides species significantly lower feces from FC, compared to (P = 0.030 P 0.021). After taking VSL#3, the Lactobacillus, increased 0.022, 0.018, 0.076), but not FC. Mean Bristol scores complete spontaneous bowel movements (CSBMs)/week ingesting (both Conclusions might be quantitatively altered A can improve clinical symptoms Further studies are needed investigate VSL#3's additional effects beyond altering allevate constipation.