Signal transduction by the Wnt family of ligands.

摘要: The Wnt genes encode a large family of secreted polypeptides that mediate cell-cell communication in diverse developmental processes. loss or inappropriate activation expression has been shown to alter cell fate, morphogenesis and mitogenesis. Recent progress identified receptors components an intracellular signalling pathway Wnt-dependent transcription. This review will highlight this 'core' signal-transduction pathway, but also aims reveal the potential diversity targets. Particular attention be paid overlap between biology oncogenesis, since recent shows forms paradigm for interdisciplinary approach.