Ritonavir boosted indinavir treatment as a simplified maintenance "mono"-therapy for HIV infection.
作者： Christian Kahlert , Maria Hupfer , Thomas Wagels , Daniel Bueche , Walter Fierz
DOI: 10.1097/00002030-200404090-00017
关键词: Biology 、 Immunology 、 Maintenance therapy 、 Indinavir 、 Acquired immunodeficiency syndrome (AIDS) 、 Lentivirus 、 Viral disease 、 Ritonavir 、 Sida 、 Internal medicine 、 Protease inhibitor (pharmacology)
摘要: Triple combination is currently the fundamental concept for HIV therapy. We evaluated feasibility of a 48-week maintenance therapy with ritonavir-boosted indinavir in 12 HIV-infected patients. All patients maintained viral suppression (< 50 copies/ml) throughout study (one drop-out after week 32) and opted to continue on this monotherapy thereafter. At 48, no changes fat distribution patterns were detectable using dual-energy X-ray absorptiometry scan. These results support further evaluation mono-maintenance trials.
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