Measuring the linear and nonlinear elastic properties of brain tissue with shear waves and inverse analysis

摘要: We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured velocities plane waves induced by acoustic radiation force at different states pre-deformation when ultrasonic probe is pushed into soft tissue. relied on an inverse method based theory governing propagation small-amplitude in deformed solids interpret experimental data. found that, depending subjects, resulting initial modulus [Formula: see text] varies from 1.8 3.2 kPa, stiffening parameter hyperelastic Demiray-Fung model 0.13 0.73, third- fourth-order constants weakly elasticity text]1.3 text]20.6 kPa 3.1 8.7 kPa, respectively. Paired test performed results left right lobes shows no significant difference. These values are line with those reported literature tissue, indicating that SSI method, combined analysis, efficient powerful tool for mechanical characterization which great importance computer simulation traumatic injury virtual neurosurgery.