Sustained expression of interleukin-1β in mouse hippocampus impairs spatial memory

摘要: Abstract Glial activation and neuroinflammation occur in neurodegenerative disease brain injury, however their presence normal aging suggests that chronic may be a factor age-related dementia. Few studies have investigated the impact of sustained elevation hippocampal interleukin-1β, pro-inflammatory cytokine upregulated during Alzheimer's disease, on cognition mice. We utilized IL-1β XAT transgenic mouse to initiate bilateral overexpression interleukin-1β determine influence independent pathology. Fourteen days following transgene induction, adult male female mice were tested non-spatial spatial versions Morris water maze. For component, one retention trial was conducted 48 h after completion 3 day acquisition protocol (eight trials per day). Induction did not learning, but associated with delayed decreased task. These behavioral impairments accompanied by robust reactive gliosis elevated mRNA expression inflammatory genes hippocampus. Our results suggest prolonged response se mnemonic processes support future application investigate age- pathology-related cognitive dysfunction.