Drug Discovery at the Enzyme Level

摘要: This chapter deals with enzymes as targets of drug action. The focus is on inhibition enzyme activity by drugs, although other actions drugs are possible, such activation or allosteric modification function. will not deal themselves e. g., L-asparaginase in the treatment acute lymphocytic leukemia, papain used for proteolysis wound debridement, and urokinase thrombolytic therapy. Metabolism induction drug-metabolizing drug-enzyme interactions that can be important considerations development, but our entirely a primary mechanism to which owe their efficacy. We consider how assayed, inhibitors found (or made) characterized, demonstrated vivo, some specific examples drugs.