The effects of decabromodiphenyl ether on glycolipid metabolism and related signaling pathways in mice.
作者： Yupeng Zhu , Xiangyang Li , Jianhui Liu , Guiqing Zhou , Yang Yu
DOI: 10.1016/J.CHEMOSPHERE.2019.02.003
关键词: Oxidative stress 、 Decabromodiphenyl ether 、 Internal medicine 、 Adipose tissue 、 Lipid metabolism 、 Endocrinology 、 Carbohydrate metabolism 、 Chemistry 、 PI3K/AKT/mTOR pathway 、 GLUT4 、 Protein kinase B
摘要: Abstract Decabromodiphenyl ether (BDE-209), an addictive type flame retardant, is widely found in environments, and could affect the glycolipid metabolism. The present study was designed to investigate potential mechanism of BDE-209 affecting Forty mice were randomly divided into four groups, they exposed BDE-209 at dosages 0, 7.5, 25 75 mg kg−1·d−1 for 28 d, respectively. results showed that increased serum levels glucose, insulin, triglyceride, also decreased level high-density lipoprotein, damaged structures liver adipose tissue mice. significantly protein expression p-IRS, markedly expressions PI3K, p-AKT, GLUT4, improved lipid metabolism related factor p-mTOR, mTOR, PPARγ RXRɑ, inhibited activity antioxidant enzymes These suggested glucose inhibiting PI3K/AKT/GLUT4 signaling pathway resulting from improving p-IRS expression, interfered with through activate mTOR/PPARγ/RXRα oxidative stress
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