Changes in energy expenditure and fat metabolism in rats infused with interleukin-1.

摘要: Metabolic alterations related to resting energy expenditure (REE) and fat metabolism have been noted during sepsis, often depend on the causative agent stage severity of illness. We studied effect IL-1, protein mediator 'acute phase' response infection, REE, respiratory quotient (RQ), in male rats (210 g), who were infused over an 8-h period with (1-14C)-palmitate (PALM), (2-3H)-glycerol (GLY) either saline or interleukin-1 (IL-1). At 7-8 h post infusion, IL-1 group showed a significant increase REE but no change RQ. The also exhibited decrease serum free fatty acid (FFA) FFA clearance. Free flux, %PALM oxidation, (GLY), glycerol clearance, flux (a measure lipolytic rate) not significantly different between two groups. conclude that can mimic seen infection; is due selective oxidation only, although unchanged RQ increased suggest there proportional net oxidation.