High density lipoprotein cholesterol and cancer: Marker or causative?

摘要: The relationship between high-density lipoproteins (HDLs), HDL-cholesterol (HDLC) and cancer incidence mortality is controversial. Although most studies conducted so far, including well-designed prospective meta-analyses, have revealed a significant inverse association HDL-C levels risk, several confounding factors opposite results showing either direct or an hindered the possibility to derive definitive conclusions. Moreover, different lines of research also pointed out that this might actually reflect causality, which would imply low merely represent epiphenomenon cancer-related inflammation cell renewal. Accordingly, pharmacological increase plasma in large lipid modifying trials has not resulted amelioration outcomes. In such intricate scenario, we comprehensive review literature with aim provide wide perspective on HDLs, mild extreme changes mortality, touching upon certainties, failures open issues intriguing area research.