Neoadjuvant Hormonal Therapy Before Radical Prostatectomy Decreases the Number of Positive Surgical Margins in Stage T2 Prostate Cancer: Interim Results of a Prospective Randomized Trial
作者： Hein Van Poppel , Dirk De Ridder , Aziz A. Elgamal , Wim Van de Voorde , Patrick Werbrouck
DOI: 10.1016/S0022-5347(01)67068-X
关键词: Randomized controlled trial 、 Hormonal therapy 、 Urology 、 Prostate 、 Prostatectomy 、 Estramustine 、 Medicine 、 Antiandrogen 、 Prostate cancer 、 Stage (cooking)
摘要: AbstractPurpose: We investigated the effect of neoadjuvant treatment before radical prostatectomy for clinically localized prostate cancer.Materials and Methods: A total 130 patients with stages T2b T3 cancer was randomized in a multicenter study: 62 underwent immediate 65 received 560 mg. estramustine phosphate daily 6 weeks preoperatively.Results: For clinical stage tumors resulted significant decrease positive surgical margins compared to nonpretreated group. This difference not found tumors. The impact on progression survival still must be analyzed.Conclusions: Neoadjuvant can beneficial T2 cancer. Optimal remains controversial.
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