Fabrication of highly porous biodegradable biomimetic nanocomposite as advanced bone tissue scaffold
作者： Abdalla Abdal-hay , Khalil Abdelrazek Khalil , Abdel Salam Hamdy , Fawzi F. Al-Jassir
DOI: 10.1016/J.ARABJC.2016.09.021
关键词: Chemical engineering 、 Tissue engineering 、 Bone tissue 、 Microporous material 、 Nanocomposite 、 Composite number 、 Scaffold 、 Nanoparticle 、 Chemistry 、 Apatite
摘要: Development of bioinspired or biomimetic materials is currently a challenge in the field tissue regeneration. In-situ 3D microporous nanocomposite scaffold has been developed using simple lyophilization post hydrothermal reaction for bone healing applications. The fabricated porous possesses advantages good bonelike apatite particles distribution, thermal properties and high interconnected network structure. High dispersion nanoparticles (NPs) rapidly nucleated deposited from surrounding biological minerals within chitosan (CTS) matrices technique. After that, freeze-drying method was applied on composite solution to form desired architecture. Interestingly, porosity pore size were not significantly affected by content CTS matrix. Our results demonstrated that compression modulus twice higher than plain scaffold, indicating maximization chemical interaction between polymer matrix NPs. Cytocompatibility test MC3T3-E1 pre-osteoblasts cell line MTT-indirect assay showed proliferation growth pure scaffold. Collectively, our suggest newly highly apatite/CTS as an alternative hydroxyapatite/CTS may serve excellent platform
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