Vitamin D levels in prepubertal children in Southern Tasmania: prevalence and determinants.

摘要: Objective: To describe the prevalence and determinants of 25-hydroxy D3(25(OH)D) in children. Design: Cross-sectional study. Setting: Southern Tasmania between June November 1997. Subjects: Two hundred one 8-y old male female children taking part a cohort study whose principal endpoints were blood pressure high-density lipoprotein (HDL) cholesterol. Results: The mean 25(OH)D level was 79 nmol/l (s.d. 29.5, median 73, range 12–222). Boys had higher levels than girls (82.1 vs 72.8 nmol/l, P=0.02). associated with sunlight exposure winter school holidays (r=0.20, P=0.005) weekends (r=0.16, P=0.02), month after (87.5 69.5 nmol, P<0.0001) body mass index (r=−0.23, P=0.001). Dietary intake vitamin D low (mean 40 IU/day, 5.2–384) not (r=0.01, P=0.91). Variation skin melanin density weakly (r=0.09, P=0.19). Conclusions: Sunlight is major determinant stores our population. Neither variation type within Caucasians nor diet modified this association to any significant extent. Extrapolation these findings bone associations very similar population suggests that minimum around 50 nmol/l required for optimal development prepubertal but needs be confirmed further controlled trials supplementation mass. Sponsorship: Arthritis Foundation Australia, Roche Pharmaceuticals.