Splanchnic exchange of amino acids after amino acid ingestion in patients with chronic renal insufficiency.

作者: G Deferrari , G Garibotto , C Robaudo , M Sala , A Tizianello

DOI: 10.1093/AJCN/48.1.72

关键词: IsoleucineMetabolismPostprandialGlutaminePhenylalanineIngestionEndocrinologyAmino acidMedicineSplanchnicInternal medicine

摘要: Splanchnic exchange (net uptake or release) of amino acids (AAs) was evaluated by measuring arterial-hepatic venous differences for AAs and hepatic blood flow in patients with chronic renal insufficiency (CRI) control subjects before 70 min after the ingestion an AA mixture simulating animal protein meal. In CRI ingestion, splanchnic area total nonessential (NEAAs) is increased 135% over because augmented escape proline, glutamate, serine, glycine, alanine, cyst(e)ine; contrarily, glutamine shows uptake. essential (EAAs) only 67% controls a higher threonine, isoleucine, phenylalanine, histidine. Abnormalities arterial areas parallel those except isoleucine. Data indicate that CRI, at least meal, organs metabolize abnormally ingested export unbalanced bulk AAs, severely affecting postprandial profile AAs.

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