Fatal brodifacoum rodenticide poisoning: autopsy and toxicologic findings.

摘要: This report details the pathologic and toxicologic findings in case of a 15-year-old girl who deliberately fatally ingested brodifacoum, commonly used rodenticide. The mechanism death, massive pulmonary hemorrhage, has not been previously reported. Brodifacoum was quantitated liver, spleen, lung, brain, bile, vitreous humor, heart blood, femoral blood using HPLC with fluorescence detection. highest brodifacoum concentrations were detected bile (4276 ng/mL) (3919 ng/mL). No brain or humor. A concentration 50 ng/g observed frozen liver while formalin fixed exhibited 820 ng/g. very high blood:liver ratio suggested acute poisoning but historical longer period anticoagulation. Though most cases humans are non-fatal, this compound can be deadly because its long half-life. Forensic pathologists toxicologists should suspect superwarfarin rodenticides when confronted unexplained bleeding. Anticoagulant mimic fatal leukemia infectious diseases such as bacterial sepsis, rickettsioses, plague, leptospirosis. thorough death scene investigation may provide clues that person these substances.