Peripheral type of choline acetyltransferase: biological and evolutionary implications for novel mechanisms in cholinergic system.

作者: J.-P. Bellier , H. Kimura

DOI: 10.1016/J.JCHEMNEU.2011.02.005

关键词: Enteric nervous systemSensory neuronAcetylcholineCholinergic neuronCholinergicCholine acetyltransferaseDorsal root ganglionPeripheral nervous systemNeuroscienceBiology

摘要: The peripheral type of choline acetyltransferase (pChAT) is an isoform the well-studied common (cChAT), synthesizing enzyme acetylcholine. Since pChAT arises by exons skipping, its amino acid sequence similar to that cChAT, except lack a continuous peptide encoded all four from 6 9. While cChAT expression has been observed in both central and nervous systems, preferentially expressed system. appears be reliable marker for visualization cholinergic neurons their processes, whereas other conventional markers including have not used successfully it. In mammals like rodents, immunoreactivity most, if all, physiologically identified structures such as parasympathetic postganglionic most enteric addition, found many are derived neural crest. These include sensory trigeminal ganglion dorsal root ganglion, sympathetic neurons. Recent studies moreover indicate pChAT, well ubiquitously among various species only vertebrate but also invertebrate mollusks. This finding implies alternative splicing mechanism generate preserved during evolution, probably some functional benefits.

参考文章(149)
Patricia E. Phelps, James E. Vaughn, Immunocytochemical localization of choline acetyltransferase in rat ventral striatum: a light and electron microscopic study. Journal of Neurocytology. ,vol. 15, pp. 595- 617 ,(1986) , 10.1007/BF01611860
Loreta Medina, Anton Reiner, Distribution of choline acetyltransferase immunoreactivity in the pigeon brain The Journal of Comparative Neurology. ,vol. 342, pp. 497- 537 ,(1994) , 10.1002/CNE.903420403
J.B. Furness, M. Costa, F. Eckenstein, Neurones localized with antibodies against choline acetyltransferase in the enteric nervous system Neuroscience Letters. ,vol. 40, pp. 105- 109 ,(1983) , 10.1016/0304-3940(83)90287-2
L.-P. Chao, F. Wolfgram, ACTIVATION, INHIBITION AND AGGREGATION OF CHOLINE ACETYLTRANSFERASE (EC 2.3.1.6) Journal of Neurochemistry. ,vol. 23, pp. 697- 701 ,(1974) , 10.1111/J.1471-4159.1974.TB04393.X
C. Cozzari, B. K. Hartman, Preparation of antibodies specific to choline acetyltransferase from bovine caudate nucleus and immunohistochemical localization of the enzyme Proceedings of the National Academy of Sciences of the United States of America. ,vol. 77, pp. 7453- 7457 ,(1980) , 10.1073/PNAS.77.12.7453
Hiroshi Ogawa, Takeshi Fujii, Yoshihiro Watanabe, Koichiro Kawashima, Expression of multiple mRNA species for choline acetyltransferase in human T-lymphocytes Life Sciences. ,vol. 72, pp. 2127- 2130 ,(2003) , 10.1016/S0024-3205(03)00072-9
John Lehmann, H.C. Fibiger, Acetylcholinesterase and the cholinergic neuron. Life Sciences. ,vol. 25, pp. 1939- 1947 ,(1979) , 10.1016/0024-3205(79)90596-4
Pu-Qing Yuan, Hiroshi Kimura, Mulugeta Million, Jean-Pierre Bellier, Lixin Wang, Gordon V. Ohning, Yvette Taché, Central vagal stimulation activates enteric cholinergic neurons in the stomach and VIP neurons in the duodenum in conscious rats Peptides. ,vol. 26, pp. 653- 664 ,(2005) , 10.1016/J.PEPTIDES.2004.11.015
R. Bartus, R. Dean, B Beer, A. Lippa, The cholinergic hypothesis of geriatric memory dysfunction Science. ,vol. 217, pp. 408- 414 ,(1982) , 10.1126/SCIENCE.7046051
Loredana D’Este, Arianna Casini, Shin Kimura, Jean-Pierre Bellier, Etsuro Ito, Hiroshi Kimura, Tindaro G. Renda, Immunohistochemical demonstration of cholinergic structures in central ganglia of the slug (Limax maximus, Limax valentianus). Neurochemistry International. ,vol. 58, pp. 605- 611 ,(2011) , 10.1016/J.NEUINT.2011.02.002