作者: J.-P. Bellier , H. Kimura
DOI: 10.1016/J.JCHEMNEU.2011.02.005
关键词: Enteric nervous system 、 Sensory neuron 、 Acetylcholine 、 Cholinergic neuron 、 Cholinergic 、 Choline acetyltransferase 、 Dorsal root ganglion 、 Peripheral nervous system 、 Neuroscience 、 Biology
摘要: The peripheral type of choline acetyltransferase (pChAT) is an isoform the well-studied common (cChAT), synthesizing enzyme acetylcholine. Since pChAT arises by exons skipping, its amino acid sequence similar to that cChAT, except lack a continuous peptide encoded all four from 6 9. While cChAT expression has been observed in both central and nervous systems, preferentially expressed system. appears be reliable marker for visualization cholinergic neurons their processes, whereas other conventional markers including have not used successfully it. In mammals like rodents, immunoreactivity most, if all, physiologically identified structures such as parasympathetic postganglionic most enteric addition, found many are derived neural crest. These include sensory trigeminal ganglion dorsal root ganglion, sympathetic neurons. Recent studies moreover indicate pChAT, well ubiquitously among various species only vertebrate but also invertebrate mollusks. This finding implies alternative splicing mechanism generate preserved during evolution, probably some functional benefits.