Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials

摘要: Abstract Purpose: The impact of different local therapy approaches on control, event-free survival, and secondary malignancies in the CESS 81, 86, EICESS 92 trials was investigated. Methods Materials: data 1058 patients with localized Ewing tumors were analyzed. Wherever feasible, a surgical approach used. In poor histologic response or intralesional marginal resections, this to be followed by radiotherapy (RT). 92, preoperative RT introduced for expected close resection margins. Definitive used cases which seemed impossible. vincristine, adriamycin, cyclophosphamide, actinomycin D ifosfamide, central primaries >100 cm 3 . etoposide, randomized against Results: rate failure 7.5% after surgery without postoperative RT, 5.3% 26.3% definitive ( p = 0.001). Event-free survival reduced 0.0001). Irradiated represented negatively selected population unfavorable tumor sites. showed comparable control that resections. Patients had improved resections wide compared receiving alone. yet number good higher latter treatment group (72.2% vs. 38.5%). Conclusion: resectable initial chemotherapy low rate. With comparable. is indicated avoid After resection, may improve control.