Molecular Pathogenesis of Spinal Cord Degeneration After Traumatic Injury

摘要: The sequence of morphologic changes that result from impact injuries to the spinal cord in experimental animal models have been described (Campbell et al., 1973; Ducker 1971; Dohrmann 1972) and biochemical parameters (Molvy Demopoulous 1977; Seligman 1977). It is evident, comparative pathologic studies, same take place most human injuries. Therefore, are valid subjects for study. post-impact alterations not immediate but instead occur over a period hours responsible permanent paraplegia, which often develops. initial impacting force actually minimal one directly causes few detectable structural changes; other organs tissues injured an identical manner show very no damage. reasons unusual sensitivity central nervous system (CNS) do permanently damage known. Different pathogenetic mechanisms degeneration minimally proposed include mechanical (Kobrine, 1975), vascular (Nelson 1977), free radical chemical (Milvy Seligmann 1977) processes. may be possible all three types processes some degree irreparable tissue cellular accompany development paraplegia or quadriplegia.