Towards the Optimal Screening Collection: A Synthesis Strategy

作者: Thomas E. Nielsen , Stuart L. Schreiber

DOI: 10.1002/ANIE.200703073

关键词: Small Molecule LibrariesBottleneckRisk analysis (engineering)Project groupProcess (engineering)Probability of successNanotechnologyPhase (combat)Computer science

摘要: … , and therefore that chemistry strategies that yield advances in … of shortcomings in synthetic chemistry, has contributed to a … chiral catalysts that impose strong diastereochemical control …

参考文章(52)
Young-kwon Kim, Midori A. Arai, Takayoshi Arai, Julia O. Lamenzo, Elton F. Dean, Nick Patterson, Paul A. Clemons, Stuart L. Schreiber, Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space. Journal of the American Chemical Society. ,vol. 126, pp. 14740- 14745 ,(2004) , 10.1021/JA048170P
Annaliese K. Franz, Philip D. Dreyfuss, Stuart L. Schreiber, Synthesis and cellular profiling of diverse organosilicon small molecules. Journal of the American Chemical Society. ,vol. 129, pp. 1020- 1021 ,(2007) , 10.1021/JA067552N
Thomas E. Nielsen, Morten Meldal, Solid-Phase Synthesis of Pyrroloisoquinolines via the Intramolecular N-Acyliminium Pictet−Spengler Reaction ACS Combinatorial Science. ,vol. 7, pp. 599- 610 ,(2005) , 10.1021/CC050008A
Rebecca M. Wilson, Samuel J. Danishefsky, Pattern recognition in retrosynthetic analysis : Snapshots in total synthesis Journal of Organic Chemistry. ,vol. 72, pp. 4293- 4305 ,(2007) , 10.1021/JO070871S
David R. Spring, Chemical genetics to chemical genomics: small molecules offer big insights. Chemical Society Reviews. ,vol. 34, pp. 472- 482 ,(2005) , 10.1039/B312875J