Methods of controlling the concentration of calcium in the serum of warm-blooded animals and pharmaceutical compositions to be used therefor
作者： Junji Kubo , Seiichi Ishizuka
DOI:
关键词: Biochemistry 、 Chemistry 、 Composition (visual arts) 、 Calcium 、 Warm-blooded 、 High calcium 、 Chromatography
摘要: The present invention relates to a method of controlling the concentration calcium in serum warm-blooded animals characterized by administration pharmaceutically effective amount 25-hydroxyvitamin D 3 -26,23-lactones expressed following formula (I) ##STR1## wherein R indicates hydrogen atom or hydroxyl group and X --O-- --O--O--, animals, pharmaceutical composition be used for which comprises above-mentioned acceptable carrier. are desirably especially treatment prevention diseases resulting from high levels serum.
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Y. Tanaka, J. K. Wichmann, H. E. Paaren, H. K. Schnoes, H. F. DeLuca, Role of kidney tissue in the production of 25-hydroxyvitamin D3-26,23-lactone and 1 alpha, 25-dihydroxyvitamin D3-26,23-lactone. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 77, pp. 6411- 6414 ,(1980) , 10.1073/PNAS.77.11.6411
Heinrich K. Schnoes, Hector F. DeLuca, Joseph K. Wichmann, Mary A. Fivizzani, Herbert E. Paaren, Process for preparing vitamin D-lactones ,(1981)
Heinrich K. Schnoes, Hector F. DeLuca, Joseph K. Wichmann, Yoko Tanaka, Herbert E. Paaren, Vitamin D-lactone derivative and process for preparing same ,(1980)