Effects of Endurance Training on the Skeletal Muscle Nitric Oxide Metabolism in Insulin-Independent Type 2 Diabetic Men—A Pilot Study
作者： Christian Brinkmann , Benedikt Schulte-Körne , Marijke Grau , Sinja Obels , Roman Kemmerling
关键词: Type 2 diabetes 、 Type 2 Diabetes Mellitus 、 Skeletal muscle 、 Internal medicine 、 Nitric oxide 、 Vastus lateralis muscle 、 Endocrinology 、 Medicine 、 Nitric oxide synthase 、 Insulin 、 Endurance training
摘要: Abstract Background: Increases in the amount of inducible nitric oxide synthase (iNOS) protein and abnormal production (NO) skeletal muscle have been suggested to be associated with peripheral insulin resistance patients type 2 diabetes mellitus (T2DM). This pilot study analyzed whether a 3-month endurance training can affect iNOS NO metabolite levels vastus lateralis insulin-independent T2DM men, thereby affecting patients` glycemic control. Furthermore, serum molecules, which shown activate expression vitro experiments, were quantified. Methods: Eight overweight/obese men (years = 61 ± 10) participated study. Muscle biopsies venous blood collections performed at T1 (6 weeks before training), T2 (1 week T3 (3 4 days after training). Protein contents determined by Western blotting, nitrite concentrations chemiluminescence, molecule enz...
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