Production of radioactive endovascular stents by implantation of 133Xe ions.
作者： S. Watanabe , A. Osa , T. Sekine , N.S. Ishioka , M. Koizumi
DOI: 10.1016/S0969-8043(98)00180-8
关键词: Stent 、 Ion 、 Nuclear medicine 、 Radiology 、 Materials science 、 Coronary stent 、 Thickening 、 Ion implantation 、 Ionizing radiation 、 Neointimal hyperplasia 、 Stent implantation
摘要: Abstract A coronary stent was made radioactive by implantation of 133Xe ions for the purpose suppressing re-narrowing part blood vessel in which is implanted. Electrons relatively low energies emitted decay may give an antiproliferative effect ionizing radiation to intimal cells within a limited range 1 mm. 133Xe+ beam accelerated at 40 or 60 keV directed several stainless steel stents mounted on target-holder table that could revolve and move up down distribute as well among stents. The produced contained 100 kBq were implanted into abdominal aortas rabbits. Neointimal thickening analyzed histomorphometry samples taken 4 weeks after implantation. results indicate have potential suppress neointimal hyperplasia
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