The Quality of the Evidence According to GRADE Is Predominantly Low or Very Low in Oral Health Systematic Reviews

摘要: OBJECTIVES The main objective was to assess the credibility of evidence using Grades Recommendation, Assessment, Development, and Evaluation (GRADE) in oral health systematic reviews on Cochrane Database Systematic Reviews (CDSR) elsewhere. STUDY DESIGN AND SETTING Systematic or meta-analyses (January 2008-December 2013) from 14 high impact general dental specialty journals were screened for meta-analyses. Data collected at review, meta-analysis trial level. Two reviewers applied agreed GRADE rating selected meta-analyses. RESULTS From 510 initially identified 91 (41 50 non-Cochrane) eligible inclusion. The quality 2% moderate 18% included with no difference between non-Cochrane reviews, journal factor year publication. most common domains prompting downgrading study limitations (risk bias) imprecision play chance). CONCLUSION The assessed is predominantly low very suggesting a pressing need more randomised clinical trials other studies higher order inform decisions thereby reducing risk instituting potentially ineffective and/or harmful therapies.