Absans epilepsinin genetik siçan modeli olan WAG/Rij siçanlarin beyin dokularinda Fetuin-A ekspresyonu The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy

作者: Kadir Demircan , Gönül Gürol , Ramazan Yüksel , Didem Güneri , Fatih Ekici

DOI:

关键词: EndocrinologyCortex (anatomy)Rat modelWestern blotInternal medicineAnesthesiaMedicineThalamusEpilepsyFetuinEpilepsy treatment

摘要: Objective: In the present study, we aimed to determine Fetuin-A levels in different regions of brain absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats order contribute identification new poten tial biomarkers diagnosis, prognosis and follow up epilepsy treatment. Methods: 1, 3 6 months old male WAG/Rij (n=21) with were used this study. All decapitated under anesthesia their cortex thalamus tissues isolated. groups determined by Western Blot method using standard techniques differences between densities compared.

参考文章(24)
Katsuhito Mori, Masanori Emoto, Masaaki Inaba, Fetuin-A and the cardiovascular system Advances in Clinical Chemistry. ,vol. 56, pp. 175- 195 ,(2012) , 10.1016/B978-0-12-394317-0.00010-8
Edward R. Smith, Ramin Nilforooshan, Gary Weaving, Naji Tabet, Plasma fetuin-A is associated with the severity of cognitive impairment in mild-to-moderate Alzheimer's disease. Journal of Alzheimer's Disease. ,vol. 24, pp. 327- 333 ,(2011) , 10.3233/JAD-2011-101872
A. M. L. Coenen, E. L. J. M. van Luijtelaar, Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats. Behavior Genetics. ,vol. 33, pp. 635- 655 ,(2003) , 10.1023/A:1026179013847
Annamaria Vezzani, Brain Inflammation and Seizures Epilepsy Currents. ,vol. 4, pp. 73- 75 ,(2004) , 10.1111/J.1535-7597.2004.42012.X
Demet Akin, Teresa Ravizza, Mattia Maroso, Nihan Carcak, Tugba Eryigit, Ilaria Vanzulli, Rezzan Gülhan Aker, Annamaria Vezzani, Filiz Yılmaz Onat, IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence Neurobiology of Disease. ,vol. 44, pp. 259- 269 ,(2011) , 10.1016/J.NBD.2011.05.015
Orrin Devinsky, Annamaria Vezzani, Souhel Najjar, Nihal C. De Lanerolle, Michael A. Rogawski, Glia and epilepsy: excitability and inflammation Trends in Neurosciences. ,vol. 36, pp. 174- 184 ,(2013) , 10.1016/J.TINS.2012.11.008
Evgenia Sitnikova, Gilles van Luijtelaar, Electroencephalographic Characterization of Spike-Wave Discharges in Cortex and Thalamus in WAG/Rij Rats Epilepsia. ,vol. 0, pp. 070810012536001- ??? ,(2007) , 10.1111/J.1528-1167.2007.01250.X
Ferda Bilgir, Oktay Bilgir, Levent Kebapcilar, Mehmet Calan, Fusun Ozdemirkiran, Turker Cinali, Giray Bozkaya, Soluble CD40 ligand, high sensitive C-reactive protein and fetuin-A levels in patients with essential thrombocythemia Transfusion and Apheresis Science. ,vol. 46, pp. 67- 71 ,(2012) , 10.1016/J.TRANSCI.2011.11.013
Pascal Lim, Stephane Moutereau, Tabassome Simon, Romain Gallet, Vincent Probst, Jean Ferrieres, Pascal Gueret, Nicolas Danchin, Usefulness of fetuin-A and C-reactive protein concentrations for prediction of outcome in acute coronary syndromes (from the French Registry of Acute ST-Elevation Non-ST-Elevation Myocardial Infarction [FAST-MI]). American Journal of Cardiology. ,vol. 111, pp. 31- 37 ,(2013) , 10.1016/J.AMJCARD.2012.08.042
M. Daveau, C. Davrinche, N. Djelassi, J. Lemetayer, N. Julen, M. Hiron, P. Arnaud, J.P. Lebreton, Partial hepatectomy and mediators of inflammation decrease the expression of liver α2 -HS glycoprotein gene in rats FEBS Letters. ,vol. 273, pp. 79- 81 ,(1990) , 10.1016/0014-5793(90)81055-S