Effects of cigarette smoking and propranolol in survivors of acute myocardial infarction
作者： Syed M. Jafri , Barbara C. Tilley , Robert Peters , Lonni R. Schultz , Sidney Goldstein
DOI: 10.1016/0002-9149(90)90286-A
关键词: Diabetes mellitus 、 Survival analysis 、 Retrospective cohort study 、 Medicine 、 Myocardial infarction 、 Randomized controlled trial 、 Risk factor 、 Beta blocker 、 Cardiology 、 Propranolol 、 Internal medicine 、 Cardiology and Cardiovascular Medicine
摘要: The effect of propranolol on mortality and reinfarction after acute myocardial infarction (AMI) in cigarette smokers nonsmokers was studied the Beta Blocker Heart Attack Trial. Cigarette (n = 2,332) were 5 years younger than had a lower incidence diabetes mellitus, systemic hypertension, previous AMI cardiomegaly. Among smokers, placebo group higher total rate (11.0 vs 7.4%, p less 0.0008) more sudden cardiac deaths (7.1 4.6%, 0.009). In (7.9 7.1%, greater 0.64) similar to group. After baseline adjustment, estimated have 1.6 times risk dying as compared (p 0.0007). Adjusting for differences, both treatment with nonsmoking predictors survival. No detectable nonsmoking/propranolol interaction could be identified. survivors beneficial is observed smokers. Nevertheless, smoking continues factor even those receiving propranolol.
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