Leukotrienes Play a Role in the Control of Parasite Burden in Murine Strongyloidiasis

摘要: It is clear that leukotrienes mediate inflammatory response; new aspects of leukotriene function have recently been described. In this study, we demonstrate are key chemical mediators in the control parasite burdens mice infected with Strongyloides venezuelensis. High levels were detected lungs and small intestines Swiss mice. treated MK886, a synthesis inhibitor, numbers adult worms, eggs/g/feces greater than infected-only animals. The MK886 treatment inhibited B4 production intestines, albeit on different postinfection days. Similarly, 5-lipoxygenase−/− wild-type These observation confirmed by histopathological study duodena. We subsequently observed significant lower eosinophils mononuclear cells blood, peritoneal cavity fluid, bronchoalveolar lavage fluid MK886. lung parenchyma animals, significantly IL-5 at beginning infection, whereas IL-12 increased progressively throughout period. However, C4, PGE2, TNF-α, IL-3, IL-4, IFN-γ, IL-10 comparable between untreated groups. Nevertheless, IgE IgG1 (but not IgG2a) was also administration. Therefore, S. venezuelensis-infected mice, worm egg dependent. findings indicate potential immunostimulatory strategies involving administration, may serve as an alert to physicians treating stercoralis-infected patients presenting asthma-like symptoms because use 5-lipoxygenase inhibitors worsen infection.