Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells.

摘要: The increased risk of several types cancer in Klinefelter syndrome (47XXY) suggests that the extra X chromosome may be involved tumorigenesis associated with this syndrome. Here, we show cells (PSK-1) derived from a patient showing loss an inactive subsequently gained active chromosomes. We found abnormal composition PSK-1 is caused by followed multiplication identical chromosomes, not reactivation chromosome. Furthermore, extended characterization loss-of-inactive series 22 female-derived cell lines (eight breast lines, seven ovarian and cervical lines). data demonstrate mainly achieved chromosomes However, distinctive pathways, including chromosome, are also mechanisms for gain-of-active cells. biological significance oncogenesis discussed.