Aerosol dispersion of respirable particles in narrow size distributions using drug-alone and lactose-blend formulations.

作者: Margaret D. Louey , Michiel Van Oort , Anthony J. Hickey

DOI: 10.1023/B:PHAM.0000032991.74736.3E

关键词: AerosolizationPharmacology toxicologyDrugLactoseChemical engineeringAerosol dispersionMaterials science

摘要: … micronized or spraydried fluticasone propionate (FP) particles (d50% … The presence of some amorphous material in the smallest … Although the slight amorphous content observed in the …

参考文章(16)
Anthony J. Hickey, Neville M. Concessio, Flow Properties of Selected Pharmaceutical Powders from a Vibrating Spatula Particle & Particle Systems Characterization. ,vol. 11, pp. 457- 462 ,(1994) , 10.1002/PPSC.19940110609
Margaret D. Louey, Michiel Van Oort, Anthony J. Hickey, Aerosol Dispersion of Respirable Particles in Narrow Size Distributions Produced by Jet-Milling and Spray-Drying Techniques Pharmaceutical Research. ,vol. 21, pp. 1200- 1206 ,(2004) , 10.1023/B:PHAM.0000033007.27278.60
Bernd W Müller, Hartwig Steckel, In vitro evaluation of dry powder inhalers II: influence of carrier particle size and concentration on in vitro deposition International Journal of Pharmaceutics. ,vol. 154, pp. 31- 37 ,(1997) , 10.1016/S0378-5173(97)00115-4
D Ganderton, THE GENERATION OF RESPIRABLE CLOUDS FROM COARSE POWDER AGGREGATES JOURNAL OF BIOPHARMACEUTICAL SCIENCES. ,vol. 3, pp. 101- 105 ,(1992)
I Gonda, Targeting by deposition Drugs and the pharmaceutical sciences. ,vol. 54, pp. 61- 82 ,(1992)
Paul Lucas, Kerry Anderson, John N. Staniforth, Protein Deposition from Dry Powder Inhalers: Fine Particle Multiplets as Performance Modifiers Pharmaceutical Research. ,vol. 15, pp. 562- 569 ,(1998) , 10.1023/A:1011977826711
Nora Y. K. Chew, Hak‐Kim Chan, Influence of Particle Size, Air Flow, and Inhaler Device on the Dispersion of Mannitol Powders as Aerosols Pharmaceutical Research. ,vol. 16, pp. 1098- 1103 ,(1999) , 10.1023/A:1018952203687