Longitudinal Changes in Growth Parameters Are Correlated With Changes in Pulmonary Function in Children With Cystic Fibrosis

摘要: Objective Nutritional status is associated with pulmonary health and survival in children cystic fibrosis (CF). This study evaluated the weight gain pattern of CF relation to longitudinal trends their function. Our hypothesis was that who experience continuous at a given rate will have better average forced expiratory volume 1 second (FEV(1)) change FEV(1) than patterns deviate from this rate, even when total seems adequate. Methods Prospectively collected data were examined 319 children, aged 6 8, routinely followed Minnesota Cystic Fibrosis Center. One 67 measurements (kg), height (cm), (mL) taken per child during 2-year period. The analyzed by repeated measure regression analysis growth analysis. Results At baseline, 1-kg higher initial 55-mL FEV(1). During follow-up period, an increase 32 mL. Children had steady tended greater increases experienced periodic losses weight. Conclusions We established weigh more appropriate uninterrupted trajectory. Aggressive nutritional support maintain these may therefore improve FEV(1), which can be as surrogate for lung health, ultimately lead survival.