Potential of Neural Stem Cell-Based Therapy for Parkinson’s Disease

摘要: Neural stem cell (NSC) transplantation is an emerging strategy for restoring neuronal function in neurological disorders, such as Parkinson's disease (PD), which characterized by a profound and selective loss of nigrostriatal dopaminergic (DA) neurons. Adult neurogenesis generates newborn neurons that can be observed at specialized niches where endothelial cells (ECs) play significant role regulating the behavior NSCs, including self-renewal differentiating into all neural lineage cells. In this minireview, we highlight importance establishing appropriate microenvironment target site NSC transplantation, grafted integrate surroundings order to enhance DA neurotransmission. Using novel model NSC-EC coculture, it possible combine ECs with generate neurovascular microenvironment. With NSCs selected, composition transplant investigated through paracrine juxtacrine signaling within unit (NVU). cellular acellular compartments recognized, guided differentiation achieved. As differentiated existing pathway, symptoms PD potentially alleviated reversing characteristic neurodegeneration.