Spatiotemporal Dynamics of Virus Infection Spreading in Tissues.

摘要: Virus spreading in tissues is determined by virus transport, multiplication host cells and the virus-induced immune response. Cytotoxic T remove infected with a rate infection level. The intensity of response has bell-shaped dependence on concentration virus, i.e., it increases at low decays high levels. A combination these effects time delay determine development like spleen or lymph nodes. mathematical model described this work consists reaction-diffusion equations delay. It shows that different regimes establishment level infection, transition between both are initial load dynamics solutions include simple composed waves, periodic aperiodic oscillations. results analytical numerical studies provide systematic basis for quantitative understanding interpretation determinants process target organs from image-derived data as well spatiotemporal mechanisms viral disease pathogenesis, have direct implications biopsy-based medical testing chronic processes caused viruses, e.g. HIV, HCV HBV.