Progressive Systemic Sclerosis

摘要: The visceral manifestations of scleroderma have been recognized for almost 60 years, but the relative infrequency disease and difficulty obtaining adequate pathological material have, with certain outstanding exceptions, precluded pursuit comprehensive studies. Beerman,1in an excellent review literature, stressed protean nature which Becker Obermayer2have ably defined as follows: Generalized is not strictly a dermatosis, rather connective tissue various organs systems, skin, subcutaneous tissue, muscles, bones joints, tendons fascias, serous surface, internal organs, endocrine glands nervous system. patient first notes surface alterations, consequently dermatologist usually consulted. Goetz3has suggested term "progressive systemic sclerosis" to describe clinical picture until etiology has established. According author: Progressive sclerosis