Recent advances in the field of caloric restriction mimetics and anti-aging molecules.
作者： Jan Martel , Shih-Hsin Chang , Cheng-Yeu Wu , Hsin-Hsin Peng , Tsong-Long Hwang
DOI: 10.1016/J.ARR.2020.101240
关键词: Spermidine 、 Pharmacology 、 Autophagy 、 Metformin 、 Context (language use) 、 Hormesis 、 High doses 、 Fungal Polysaccharides 、 Chemistry 、 Physiological function
摘要: Caloric restriction (CR) mimetics are molecules that produce beneficial effects on health and longevity in model organisms humans, without the challenges of maintaining a CR diet. Conventional such as metformin, rapamycin spermidine activate autophagy, leading to recycling cellular components improvement physiological function. We review here novel anti-aging compounds, 4,4'-dimethoxychalcone, fungal polysaccharides, inorganic nitrate, trientine, highlighting their possible molecular targets mechanisms action. The activity these compounds can be understood within context hormesis, biphasic dose response involves at low or moderate doses toxic high doses. concept hormesis has widespread implications for identification experimental assays, testing clinical trials, use healthy humans. also discuss promises limitations delaying aging treating chronic diseases.
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