Development of fetal hippocampal grafts in intact and lesioned hippocampus.

摘要: Functional recovery observed in Parkinson's disease patients following grafting of fetal substantia nigra has encouraged the development similar therapy for other neurological disorders. Fetal hippocampal paradigms are considerable significance because their potential to treat disorders affecting primarily hippocampus, including temporal lobe epilepsy, cerebral ischemia, stroke, and head injury. Since many recent studies transplants were carried out with an aim laying foundation future clinical applications, overview transplants, capability inducing functional under different host conditions is timely. In this review, we will summarize developments especially anatomical and/or integration grafts within brain specific conditions, a comparison intact hippocampus various types lesions or Improvements techniques, methods analysis graft function be summarized, addition critical factors which enhance survival grafted cells alternative sources donor currently being tested considered transplantation. Viewed collectively, show that tissue/cells survive grafting, establish both afferent efferent connections brain, also capable ameliorating certain learning memory deficits some models. However, efficacy intracerebral varies considerably animal models, depending on several factors: mode tissue preparation, method state at time placement hippocampus. improvement models appeared caused partially by re-establishment damaged circuitry trophic action grafts. exact mechanisms graft-mediated behavioral remain clarified due lack correlative same between degree recovery. Issues action, restoration amelioration pathological need sorted clearly prior use susceptible conditions.