Synthesis of Amino Acid Derivatives of Kojic Acid and Their Tyrosinase Inhibitory Activity

作者： Yoshikane Kobayashi , Hiroshi Kayahara , Koji Tadasa , Toshiko Nakamura , Hiroshi Tanaka

关键词: Stereochemistry 、 Kojic acid 、 Amino acid 、 Acylation 、 Enzyme inhibitor 、 Enzyme 、 IC50 、 Chemistry 、 Tyrosinase 、 Inhibitory postsynaptic potential

摘要: Six N-carbobenzozy amino acid derivatives of kojic were synthesized to improve the tyrosinase inhibitory activity acid. All showed stronger activities than Among them, L-phenylalanine derivative was strongest inhibitor and its IC50 value about 1/80 that for The inhibition mechanism these is considered be a noncompetitive one similar