A Genome-Wide Analysis of Promoter-Mediated Phenotypic Noise in Escherichia coli

摘要: Gene expression is subject to random perturbations that lead fluctuations in the rate of protein production. As a consequence, for any given protein, genetically identical organisms living constant environment will contain different amounts particular resulting phenotypes. This phenomenon known as “phenotypic noise.” In bacterial systems, previous studies have shown that, specific genes, both transcriptional and translational processes affect phenotypic noise. Here, we focus on how promoter regions genes noise ask whether levels promoter-mediated are correlated with genes' functional attributes, using data over 60% all promoters Escherichia coli. We find essential high degree evolutionary conservation confer low also level cannot be attributed time spent genome E. contrast results eukaryotes, no association between gene plasticity. These consistent hypothesis bacteria, natural selection can act reduce some this controlled through sequence region alone.