Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use

摘要: An up to 125% fluorocarbon emulsion for use in or with animal bodies and organs thereof, maintains stability through normal sterilization procedures selective osmotic buffering agents, the at within predetermined osmolarity levels and, when desired, free of excessive calcium precipitation, reduces vivo vitro red blood cell injury, adverse anemia effects, viscosity rate oxidation, tends equilibrate its distribution major body thereby reducing toxicity. The agents may buffer provide nutrient form sugars. can comprise, selectively, hexahydric alcohols, namely mannitol sorbitol; certain sugars, glucose, mannose fructose; along that will affect including imidazole, tris(hydroxymethyl)aminomethane, sodium chloride, bicarbonate, monobasic potassium phosphate, dibasic magnesium sulfate, phosphate combinations them. include tocopherol. A method emulsifying includes forced flow impingement under pressure after mixing into discontinuous phase. be used deliver drugs medicines soluble in, transportable by emulsion.