Kidney transplant monitoring by anti donor specific antibodies.
作者： N. Torlone , M. Valeri , L. Provenzani , E. Poggi , D. Adorno
DOI: 10.1007/978-3-642-77423-2_198
关键词: Kidney transplant 、 Medicine 、 Kidney transplantation 、 Donor specific antibodies 、 Kidney 、 Flow cytometry 、 Clinical course 、 Antibody 、 Immunology
摘要: Donor-specific anti-HLA antibodies were studied by cytotoxicity crossmatching (CTXM) and flow cytometry (FCXM) in 117 kidney transplant candidates; the same study was carried out 33 cadaver-donor recipients, during first 3 post-transplant months, for which donor cells available. Pre-transport evaluation showed that 82.9% of subjects CTXM negative/FCXM negative, 6.8% patients positive both tests, 10.3% negative/FCCM positive. Post-transplant monitoring donor-specific (Abs-DS) nine recipients (27.3%) FCXM positive; six them IgG + three IgM +. In comparing these results with clinical course, a significant association between IgG+ rejection episodes observed (P<0.01).
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