Identification of Regional Mechanical Anisotropy in Soft Tissue Analogs
作者： Ramesh Raghupathy , Colleen Witzenburg , Spencer P. Lake , Edward A. Sander , Victor H. Barocas
DOI: 10.1115/1.4005170
关键词: Polarized light microscopy 、 Anisotropy 、 Composite material 、 Biomedical engineering 、 Inverse 、 Work (thermodynamics) 、 Isotropy 、 Elastomer 、 Soft tissue 、 Microscopy 、 Materials science
摘要: In a previous work (Raghupathy and Barocas, 2010, "Generalized Anisotropic Inverse Mechanics for Soft Tissues,"J. Biomech. Eng., 132(8), pp. 081006), generalized anisotropic inverse mechanics method applicable to soft tissues was presented tested against simulated data. Here we demonstrate the ability of identify regional differences in anisotropy from full-field displacements boundary forces obtained biaxial extension tests on tissue analogs. Tissue heterogeneity evaluated by partitioning domain into homogeneous subdomains. Tests elastomer samples demonstrated performance isotropic materials with uniform nonuniform properties. fibroblast-remodeled collagen cruciforms indicated strong correlation between local structural (measured polarized light microscopy) mechanical anisotropy. The results potential quantify material behavior an intact sample.
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