Closed-circuit anesthesia prolongs the neuromuscular blockade of rocuronium.

摘要: Background: Volatile anesthetics are known to potentiate the neuromuscular blocking effect of nondepolarizing muscle relaxants. The influences anesthetic techniques, closed-circuit anesthesia (CCA) and high flow semi- closed (SCA), on blockade rocuronium has not yet been studied in detail This study was purposed compare effects isoflurane conveyed minimal (SCA) rocuronium. Methods: Fifty females scheduled for elective laparoscopic gynecological surgery were enrolled randomly assigned receive either CCA (n=25) or SCA (n=25). Anesthesia induced with fentany12μg/kg, thiopental 5mg/kg 0.6mg/kg. Two percent O2 (31/mim) given 10mim all patients initially wash functional residual capacity both lungs breathing circuit. After in, group, 02 reduced 300ml/min vaporizer setting adjusted 3-5% maintenance, while maintained 1.5-2% 31/mim throughout surgery. Electromyogram used determine blockade. Rocuronium (0.15mg/kg) maintain relaxation when T1 reached 25% control. We depth until recordings ofT1 twitch response which 75% completed. Onset time, duration, recovery index intubating conditions recorded. hemodynamic parameters inhaled/exhaled concentrations also measured every 15mIm after skin incision groups Results: onset time similar groups. In comparison longer clinical durations (54.1±14.4vs. 45.4±9.2min, P＜0.05), dose (41.1±11.1vs. 30.2±8.6min, P＜0.01) (34.2±10.7vs. 20.9±5.4min, P＜0.0001) observed group. Conclusions: conclude that may further prolong than SCA.