SEROTYPING FOR HOMOTRANSPLANTATION. VII. SELECTION OF KIDNEY DONORS FOR THIRTY-TWO RECIPIENTS*

摘要: An attempt was made to select donors for human kidney transplantation on the basis of lymphocyte antigen matching. Compatibility assayed by reactions individual antisera donor and recipient lymphocytes, as well matching six recognized leukocyte groups. The judged be best match chosen from pools related unrelated donors. Although choice often limited, a group selected which, whole, slightly more compatible than that achieved random Mismatches which were extremely high or 6 avoided whenever possible. Eighteen transplants done donors: sixteen these recipients lived at least 4 months postoperatively; three died after 1012, 812 8 months. Thirteen original 18 patients are still alive, 6, months, four, 21 three, one year. This represents slight improvement over first unmatched Denver series treated 2 312 years ago. Of 14 in present who received kidneys matched donors, ten months; two 5 10 respectively. Eight alive with minimum follow-up 612 four surviving 9 12 operation, other These results improved an nonselected homotransplants performed Denver. Furthermore, survival curve nonrelated now approximates obtained past experience randomly Because relatively small numbers involved, however, this is not statistically significant. Pathological studies compared dead selected. Acute vascular lesions result severe rejection less frequent earlier un-matched series. It concluded coincidental provisional types, early clinical outcome respect minimization pathologic changes associated rejection. Whether improvements attributable procedure unrecognized factors management could determined.