Complement Activation: The role in Health and Disease and Strategies of Therapeutic Complement Inhibition

摘要: The multiple interconnections among complement proteins, immune cells, and mediators provide an excellent mechanism to protect the organism against infections support repair of damaged tissues. However, disturbances in this "defense machinery" contribute pathogenesis various diseases. role inflammatory disorders is multifaceted; for example, activation can significantly inflammation-mediated tissue damage, whereas inherited or acquired deficiencies highly favor development autoimmunity. Complement as essential component system substantial relevance destruction invading microorganisms maintaining homeostasis including protection autoimmune involvement a great number partly life threatening diseases defines importance develop inhibitors which specifically interfere with its deleterious action. Endogenous soluble complement-inhibitors, antibodies low molecular weight antagonists, either blocking key proteins cascade reaction neutralizing action complement- derived anaphylatoxins have successfully been tested animal models over past years.