Results of Surgical Treatment of Renal Hyperparathyroidism

作者: Evaggelos Neonakis

DOI: 10.1001/ARCHSURG.1995.01430060081015

关键词: KidneyHyperparathyroidismSubtotal ParathyroidectomySurgeryTransplantationMedicineAutotransplantationRenal hyperparathyroidismParathyroidectomyHemodialysis

摘要: Objective: To assess the outcome of parathyroidectomy for renal failure—related hyperparathyroidism. Design: A retrospective analysis with a mean follow-up 4.34 years case series 67 consecutive patients failure—associated Setting: All were operated on at University Hospital Wales and Cardiff Royal Infirmary between October 1981 December 1991. Patients: Of patients, 35 receiving hemodialysis 32 had received transplant. Intervention: Total autotransplantation was performed in 52 subtotal 15. Main Outcome Measures: Symptomatic improvement after parathyroidectomy, normalization biochemical parameters, rate recurrent hyperparathyroidism parathyroidectomy. Results: occurred 81% 72% transplant patients. The best predictor successful relief skeletal pain an elevated preoperative alkaline phosphatase level. Recurrent developed four 38 total one 14 surviving five disease (22%). Conclusions: Transplant usually present less severe disease, have better parameters rarely develop compared Both result good control excellent symptoms. (Arch Surg. 1995;130:643-648)

参考文章(24)
H W Sollinger, J R Starling, F O Belzer, J D Pirsch, A M D'Alessandro, W B Vernon, J S Melzer, M Kalayoglu, Tertiary hyperparathyroidism after renal transplantation: operative indications. Surgery. ,vol. 106, pp. 1049- 1056 ,(1989)
Shelburne Jd, Wells Sa, Sherwood Lm, Gunnells Jc, Schneider Ab, Transplantation of the parathyroid glands in man: clinical indications and results. Surgery. ,vol. 78, pp. 34- 44 ,(1975)
William J. Johnson, James T. McCarthy, Jon A. van Heerden, Sylvester Sterioff, Clive S. Grant, Pai Chih Kao, Results of subtotal parathyroidectomy in hemodialysis patients The American Journal of Medicine. ,vol. 84, pp. 23- 32 ,(1988) , 10.1016/0002-9343(88)90004-6
Malcolm H. Wheeler, J.S.Hilary Wade, Intraoperative identification of parathyroid glands: Appraisal of methylene blue staining American Journal of Surgery. ,vol. 143, pp. 713- 716 ,(1982) , 10.1016/0002-9610(82)90043-5
Michael J. Demeure, David C. McGee, William Wilkes, Quan-Yang Duh, Orlo H. Clark, Results of surgical treatment for hyperparathyroidism associated with renal disease. American Journal of Surgery. ,vol. 160, pp. 337- 340 ,(1990) , 10.1016/S0002-9610(05)80537-9
Matthias Rothmund, Peter K. Wagner, Assessment of parathyroid graft function after autotransplantation of fresh and cryopreserved tissue World Journal of Surgery. ,vol. 8, pp. 527- 533 ,(1984) , 10.1007/BF01654930
J. Silver, J. Russell, L. M. Sherwood, Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 4270- 4273 ,(1985) , 10.1073/PNAS.82.12.4270
Anthony J. Edis, Michael D. Levitt, Supernumerary parathyroid glands: implications for the surgical treatment of secondary hyperparathyroidism World Journal of Surgery. ,vol. 11, pp. 398- 401 ,(1987) , 10.1007/BF01658128
E Slatopolsky, C Weerts, J Thielan, R Horst, H Harter, K J Martin, Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxy-cholecalciferol in uremic patients. Journal of Clinical Investigation. ,vol. 74, pp. 2136- 2143 ,(1984) , 10.1172/JCI111639