Interplay of population genetics and dynamics in the genetic control of mosquitoes

摘要: Some proposed genetics-based vector control methods aim to suppress or eliminate a mosquito population in similar manner the sterile insect technique. One approach under development Anopheles mosquitoes uses homing endonuclease genes (HEGs)—selfish genetic elements (inherited at greater than Mendelian rate) that can spread rapidly through even if they reduce fitness. HEGs have potential drive introduced traits without large-scale sustained releases. The genetics of HEG-based systems has been established using discrete-time mathematical models. However, several ecologically important aspects remain unexplored. We formulate new continuous-time (overlapping generations) combined dynamic and model apply it HEG targets knocks out gene is for survival. explore effects density dependence ranging from undercompensating overcompensating larval competition, occurring before after fitness effects, consider differences competitive effect between genotypes (wild-type, heterozygotes homozygotes). show outcomes—elimination, suppression loss HEG—depend crucially on interaction these ecological genetics, explain how properties, rate (drive) insect's life-history parameters influence those outcomes.